Cilostazol as a chemically induced preclinical model of migraine
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A Potential Preclinical Migraine Model: CGRP-Sensitized Mice.
The neuropeptide calcitonin gene-related peptide (CGRP) plays a key role in migraine. However, a major challenge for studying CGRP actions is the lack of animal models for migraine. Clinical studies suggested that migraineurs are more sensitive to CGRP than people who do not suffer from migraine. We therefore generated a transgenic mouse that is sensitized to CGRP (nestin/hRAMP1 mice). The mice...
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ژورنال
عنوان ژورنال: Cephalalgia
سال: 2017
ISSN: 0333-1024,1468-2982
DOI: 10.1177/0333102417693832